Clinical Trials in Degenerative Diseases

PERSPECTIVE
Year
: 2017  |  Volume : 2  |  Issue : 4  |  Page : 108--111

The role of oral anticoagulation therapy in pulmonary arterial hypertension


Eleni Vrigkou1, Argyrios Tsantes2, Athanasios Pappas1, Iraklis Tsangaris1 
1 Second Department of Critical Care Medicine, Attiko University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
2 Laboratory of Hematology & Blood Bank Unit, Attiko University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece

Correspondence Address:
Eleni Vrigkou
Second Department of Critical Care Medicine, Attiko University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens
Greece

Pulmonary arterial hypertension (PAH) is a severe, progressive disease characterized by increased pulmonary vascular resistance and right-sided heart failure. Despite the advances in PAH medical treatment, morbidity and mortality rates remain high. Oral anticoagulants are part of the supporting PAH treatment scheme, even though their use is based mainly on non-controlled, single-centered observational studies. The conflicting current research, the potential side effects of the anticoagulation treatment and the ambiguity of the European Society of Cardiology and European Respiratory Society pulmonary hypertension guidelines have raised concerns regarding the implementation of this intervention and heterogeneity in its application in every day clinical practice. A careful selection of the patient subgroups that oral anticoagulation therapy could be beneficial, a consideration of individual patient characteristics and a close monitoring of the anticoagulation treatment could be of importance in order to limit clinician’s concerns and minimize any potential side effects.


How to cite this article:
Vrigkou E, Tsantes A, Pappas A, Tsangaris I. The role of oral anticoagulation therapy in pulmonary arterial hypertension.Clin Trials Degener Dis 2017;2:108-111


How to cite this URL:
Vrigkou E, Tsantes A, Pappas A, Tsangaris I. The role of oral anticoagulation therapy in pulmonary arterial hypertension. Clin Trials Degener Dis [serial online] 2017 [cited 2020 Feb 27 ];2:108-111
Available from: http://www.clinicaltdd.com/article.asp?issn=2542-3975;year=2017;volume=2;issue=4;spage=108;epage=111;aulast=Vrigkou;type=0